Table 2

Sources of alleles in 502 subgroup III isolates

LocusAncestral alleleNo. of variant alleles
MutationImportTranslocation
iga iga2 1 (iga1)1 (iga3)
IS1106AUncertain8 (IS1106A4-11)*
pgm pgm3 1 (pgm11)1 (pgm19)
opaB opaB92 1 (opaB93)2 (opaB94,5202)12 (5× opaA; 4× opaD; 3× opaJ)
opaD opaD131 1 (opaD100)8 (7× opaJ; 1× opaB)
tbpB tbpB1 28 (19× family 1; 6× family 4; 3× family 3)
  • * The mechanism by which one additional IS1106A allele (IS1106A99) arose is unclear because that allele is associated with a 12-kb region that has not been sequenced (see supplemental data). 

  • The mutation in opaB93 is a 12-bp deletion. Translocations into opaB: from opaA: opaB102, 113, 115, 139, 141; from opaD: opaB100, 114, 131, 1131; from opaJ: opaB116, 140, 142. Translocations into opaD: from opaJ: opaD101, 108, 109, 110, 111, 112, 1101; from opaB: opaD94.