Table 1

CD4+CD25+ T cells reduce the number of CD8+ memory cells in mice mainly by acting on dividing cells

ExperimentRecipientCells transferred into T cell-deficient recipients Number (×10−4) of CFSE+CD8+ memory T cells recovered from animals that received Change in yield of CFSE+CD8+ memory T cells in the absence/presence of CD4+CD25+ T cells
Filler cells lacking CD4+CD25+ cells Number (×10−7) CFSE+ indicator cellsNumber (×10−6) CD25+ or CD25− test cellsCD4+CD25− test T cells CD4+CD25+ test T cells
OriginNumber (×10−7)NondividingDividingNondividingDividingNondividingDividing
1RagKOCD25KO731.73.1372.68.51.194.35
2RagKOCD25KO7.52.524.97.43.22.71.532.74
3RagKOSorted180.55.2644.28.11.247.90
4IrradiatedSorted2.76.324.36.9108.20.430.84
5RagKOAnti-CD251361.39.612.72.43.14.004.10
6IrradiatedAnti-CD47.52.319.922.55.45.51.834.09
  • Recovered memory cell numbers are those of the CD44high or IL-2Rβhigh CD8+CFSE+ cells in the spleen and inguinal, brachial, and mesenteric lymph nodes of recipients.