Table 1

Percentage of sequence similarity between VP1 coding regions of AAV serotypes 1, 2, 3, 4, 6, 7, and 8

AAV1_VP1AAV2_VP1AAV3_VP1AAV3B_VP1AAV4_VP1AAV6_VP1AAV7_VP1AAV8_VP1
AAV1_VP1 100 83 86 87 63 99 85 84
AAV2_VP180 100 88 88 60 83 82 83
AAV3_VP18082 100 99 62 86 84 85
AAV3B_VP18082100 100 63 87 84 86
AAV4_VP168666868 100 63 63 63
AAV6_VP19780808068 100 85 84
AAV7_VP1847880806884 100 88
AAV8_VP183798080688386 100
  • Multiple sequence alignments of nucleic acid and amino acid of VP1 of different serotype AAVs were performed using the VECTOR NTI 6.0 (Informax, Bethesda, MD) program. AAV5 sequence was excluded from the alignment because of its strong divergence from other serotypes. Bold numbers represent similarity in amino acid sequences whereas light face numbers indicate similarity in nucleic acid sequences. The underlined numbers represent similarity in both.