Table 4

Expression of β-unit of rhCG in mouse muscle and liver

VectorMuscleLiver
AAV2/14.5  ± 2.11.6  ± 1.0
AAV20.5  ± 0.10.7  ± 0.3
AAV2/5ND*4.8  ± 0.8
AAV2/714.2  ± 2.48.2  ± 4.3
AAV2/84.0  ± 0.776.0  ± 22.8
  • CMVCG and TBGCG minigene cassettes were used for muscle and liver-directed gene transfer, respectively. Levels of rhCG were defined as relative units (rU × 103). The data were from assaying serum samples collected at day 28, post vector administration (four animals per group). 

  • * ND, Not determined in this experiment.