Table 1

Quantification of tumors arising in the colons of Pparγ+/+ and Pparγ+/− mice following chemical or genetic carcinogenesis

GenotypenTumors/mouse% tumors (incidence)
Chemical
Dose (azoxymethane)
 0 mg/kg*Pparγ+/+100 0
Pparγ+/−100 0
 3.5 mg/kg*Pparγ+/+120.42  ± 0.5142 (5/12)
Pparγ+/−151.47  ± 1.2567 (10/15)
 7.0 mg/kgPparγ+/+103.2  ± 2.590 (9/10)
Pparγ+/−178.06  ± 5.9§100 (17/17)
Genetic
APC status
Apc+/+Pparγ+/+1000
Pparγ+/−1000
Apc+/1638NPparγ+/+171.41  ± 1.3764.7 (11/17)
Pparγ+/−201.85  ± 1.7565 (13/20)
  • Tumors were counted following euthanasia due to rectal bleeding, morbidity, or at 50 (*) weeks post-azoxymethane or saline treatment or 65 (†) weeks of age.  

  • , P < 0.05,  

  • § , P < 0.01 compared to Pparγ+/+ treated with the same dose of azoxymethane.  

  • No difference in the number of polyps arising in colons of Pparγ+/+ and Pparγ+/− mice on the Apc+/1638N background, P = 0.41.