Table 1.

Inhibitory effect on the Rev-dependent luciferase expression

Inhibition of Rev-mediated expression IC50, μMInhibition of Rev-independent expression IC50, μMToxicity CC50, μM
LMB0.0005>0.125>0.125
PKF050-6380.041.903.10
PKF050-6371.98>3.30>3.30
  • * Concentration of inhibitor required for 50% inhibition of Rev-dependent luciferase expression in transfected Jurkat cells.

  • Concentration of inhibitor required for 50% inhibition of luciferase expression from the CMV promoter in transfected Jurkat cells.

  • Concentration of inhibitor required for 50% inhibition of cell proliferation as measured by a tetrazolium-based viability assay.