Table 1.

Mutation spectrum of lacI mutants

WT (%)Mbd4−/− (%)
Base substitutions41 (76)60 (82)
 Transitions23 (43)51 (70)
  C:G→T:A, all20 (37)47 (64)
   At CpG sites15 (28)45 (62)
   At non-CpG sites5 (9)2 (3)
  T:A→C:G3 (6)4 (5)
 Transversions18 (33)9 (12)
  C:G→A:T9 (17)4 (5)
  C:G→G:C4 (7)1 (1)
  T:A→G:C2 (4)1 (1)
  T:A→A:T3 (6)3 (4)
Insertions/deletions13 (24)13 (18)
 Insertions13 (24)12 (16)
 Deletions0 (0)1 (1)
Total sequences54 (100)73 (100)
  • Compared with WT mice:

  • * , P = 0.01;

  • , P = 0.001; χ2 test.