Table 6.

Sequence Analysis of Apc mutations in Apc1638N/+ and Mbd4−/−/Apc1638N tumors

CodonMutationConsequenceWild-type sequenceWT/Apc1638N/+Mbd4−/−/Apc1638N/+
803C→TArg→Stop GCC AAT CGA CAT GAT 3
854C→TArg→Stop GAG AGA GAG CGA GGT 8
874C→TArg→Stop TCA AAA CGA GGT CTG 12
921C→TArg→Stop GCG GCA CGA AGA AGC 25
934ins TACAframeshift AAC ACA TAC AAC TTC 1
939G→TGlu→Stop AAG TCG GAA AAT TCA 1
956C→TArg→Stop TAT AAA CGA TCT TCA 7
989G→TGlu→Stop GAT GAT GAA AGT AAA 1
992del 8bp, ins Aframeshift AAA TTT TGC AGT TAT 1
993C→ACys→Stop AAA TTT TGC AGT TAT 1
1018G→TGlu→Stop GAT GGA GAA CTG GAT 1
1047G→ATrp→Stop GAA AGG TGG GCA AGA 1
1112C→TArg→Stop ACA AAT CGA ATG GGT 2
1128del GTframeshift TCT CTG TGT CAG GAA 1
1195C→ASer→Stop TCA TTT TCA TTC TCA 1
1287del 8bpframeshift GGA TGT GAT CAG ACA 1
1334C→TArg→Stop CCC AGC CGA CTC CAG 1
Total734
  • * Site of mutation is shown in bold.

  • Combined with data from ref. 20. ins, insertion; del, deletion.