Table 1.

Pheophorbide a phototoxicity in mice

Dosage, mg/kg/dayWild-typeBcrp1−/−
 1na
 2na+11
 4na+8
 8+5
 16+2
 32na
 64na
100na
200na
  • Pheophorbide a was administered orally for up to 12 days to mice fed with “normal” food (n = 3 per group). na, Not analyzed; —, no phototoxicity observed; +, phototoxicity observed; superscript numbers, average number of days until phototoxicity was first observed.

  • * Moribund mice were killed after 3 days. Light conditions are specified in Materials and Methods.