Table 1

Trapping of foreign DNA during transformation with hybrid molecules

Donor DNA type of eventR304 (chromosomal) point mutation transferpR313 ccc plasmid integration*Linear pR313 InsDel
SmR ml−10.99  × 106
MTXR ml−11.45  × 1062.02  × 104
EryR ml−11.31  × 1068.6  × 103
EryR/MTXR0.900.47
  • * The most frequent event occurring with covalently closed circles (ccc) donors is integration of the entire plasmid (34). InsDel represent 5% of total events with ccc donors (unpublished observations).