Table 1

Hematologic parameters, spleen/body weight ratios, and venular hemodynamics

GenotypeLeukocytes, ×103/μlHematocrit, %Platelets, ×103/μlSpleen/body weight ratios, g/g × 10−3VRBC, mm/s Venular diameters, μm
IVM 1IVM 2IVM 1IVM 2
WT4.3  ± 0.641.1  ± 1.5722  ± 562.5  ± 0.12.3  ± 0.12.4  ± 0.221.9  ± 0.821.8  ± 1.0
SA7.4  ± 1.833.4  ± 2.11364  ± 1262.9  ± 0.1*2.2  ± 0.12.0  ± 0.120.2  ± 1.221.7  ± 1.2
SS22.3  ± 2.4*13.1  ± 0.8287  ± 2127.3  ± 2.72.2  ± 0.10.6  ± 0.220.9  ± 1.324.9  ± 1.8
SSP/E −/−72.1  ± 11.418.2  ± 4.7331  ± 72*36.0  ± 3.32.6  ± 0.11.9  ± 0.120.4  ± 1.520.3  ± 1.2
  • Blood counts were determined using an automatic cell counter. Centerline velocities (VRBC) were measured in real time by using an optical doppler velocimeter. Venular diameters were assessed using a video caliper. n = 4–9 mice for blood counts; n = 23–41 venules from 4–5 mice for hemodynamic characteristics. 

  • * , P < 0.05 compared to WT animals.  

  • , P < 0.001 compared to WT animals.  

  • , P < 0.0001 compared to WT animals.