Table 1

Expression of the human γ gene in the transgenic mice carrying the μLCR (−382)Aγ(mut TATA) construct

LineCopy numberHuman γ % of murine α-like mRNA per copy
Embryonic erythropoiesis Definitive erythropoiesis
Day 10 Day 12 Day 12 Day 16 Adult
BloodYolk sacBloodYolk sacFetal liverBloodFetal liverBlood
μLCR(−382)Aγ(mut TATA)
 A64.2  ± 0.37.6  ± 1.013.5  ± 4.819.3  ± 1.212.0  ± 1.112.0  ± 3.47.7  ± 1.14.3  ± 1.2
 B243.5  ± 0.26.5  ± 1.18.8  ± 1.216.0  ± 1.97.1  ± 1.94.4  ± 0.94.1  ± 0.42.0  ± 0.5
 C166.5  ± 0.89.4  ± 1.717.6  ± 1.827.5  ± 6.414.8  ± 1.19.1  ± 2.97.5  ± 1.12.6  ± 0.8
 D84.3  ± 0.77.8  ± 1.18.8  ± 2.619.0  ± 3.112.1  ± 2.39.2  ± 1.09.9  ± 1.94.9  ± 0.9
Mean 4.6  ± 1.3 7.8  ± 1.2 12.2  ± 4.2 20.5  ± 4.9 11.5  ± 3.2 8.7  ± 3.2 7.3  ± 2.4 3.5  ± 1.4
μLCR(−382)Aγ*
Mean 5.7  ± 6.3 5.2  ± 3.3 10.4  ± 9.5 21.0  ± 7.4 11.8  ± 2.8 13.4  ± 4.7 15.7  ± 4.8 16.5  ± 4.5
  • * Refs. 20 and 25