Table 2

Effects of SSR149415 and diazepam in the light/dark test in mice

CompoundDose, mg/kgTime lit box, sTunnel crossings
Diazepam032.3  ± 12.24.5  ± 1
 (i.p.)0.360.1  ± 12.116.6  ± 3.4*
174.56  ± 14.2*13.5  ± 1.2*
396.3  ± 10.5*18.1  ± 1.7*
10104.2  ± 23.1*6.6  ± 2
SSR149415012.06  ± 5.65.5  ± 1.8
 (i.p.)153.1  ± 10.7*13.9  ± 2.9*
339.7  ± 10.115.9  ± 2.3
1065.7  ± 13.5*15.9  ± 3*
3047.9  ± 10.4*11.4  ± 2.1
  • Data represent mean ± SEM; 

  • * , P < 0.05 (Kruskal-Wallis test). n = 13–16.