Table 1.

Identified amino acid substitution mutations in Notch receptors and pathway genes in primary and immortalized cSCCs

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  • Shaded regions were not assessed (cell lines were Sanger sequenced for 30/34 exons each of NOTCH1 and NOTCH2 only). *denotes stop codons; bold/italicized changes are homozygous. RBJP, MAML1-3, and JAG1 mutations were not identified in any samples (data not shown).