Table 1.

Reduced chromosome numbers in late-generation ALT survivors

StrainF40F50F80F220
wildtype6.0 ± 0.0 (n = 13)NDNDND
c1-1s3.9 ± 0.4 (n = 21)2.8 ± 0.4 (n = 19)3.0 ± 0.4 (n = 20)2.8 ± 0.4 (n = 15)
c1-2s3.8 ± 0.5 (n = 20)2.9 ± 0.3 (n = 18)2.9 ± 0.3 (n = 14)2.9 ± 0.3 (n = 15)
c3-1s3.8 ± 0.4 (n = 24)2.8 ± 0.4 (n = 22)2.9 ± 0.4 (n = 20)2.9 ± 0.3 (n = 15)
c5-2s2.9 ± 0.3 (n = 16)3.1 ± 0.1 (n = 20)3.0 ± 0.0 (n = 10)ND
c7-4s4.2 ± 0.6 (n = 15)3.0 ± 0.2 (n = 20)2.9 ± 0.3 (n = 14)3.1 ± 0.4 (n = 17)
m3-4l4.8 ± 0.5 (n = 19)2.7 ± 0.5 (n = 18)2.9 ± 0.4 (n = 16)ND
m9-3m4.8 ± 0.4 (n = 27)2.9 ± 0.2 (n = 17)3.0 ± 0.0 (n = 16)2.8 ± 0.4 (n = 18)
  • Whole worms were stained with DAPI, and condensed chromosomes were counted in the nuclei of 3–5 oocytes per worm in the indicated number of worms.