Table 1.

Plasma and urine electrolytes of WNK4+/+ and WNK4−/− mice on a normal diet

ElectrolyteWNK4+/+WNK4−/−
Plasma
 Na+ (mM)152.61 ± 0.53 (15)153.19 ± 1.06 (19)
 K+ (mM)4.00 ± 0.08 (15)3.46 ± 0.1 (19)***
 Cl (mM)118.24 ± 0.52 (15)113.92 ± 1.28 (19)*
 CO2 (mM)13.93 ± 0.65 (15)16.02 ± 0.58 (19)*
 Ca2+ (mg/dL)8.43 ± 0.09 (15)8.38 ± 0.15 (19)
 Mg2+ (mg/dL)2.31 ± 0.07 (15)1.97 ± 0.07 (19)**
 Creatinine (mg/dL)0.15 ± 0.02 (15)0.17 ± 0.02 (19)
Urine
 Na+ (mmol/mmol Cr)40.88 ± 1.78 (9)49.07 ± 2.3 (7)*
 K+ (mmol/mmol Cr)70.44 ± 5.87 (9)109.27 ± 5.03 (7)**
 Cl (mmol/mmol Cr)58.82 ± 4.12 (9)81.42 ± 3.36 (7)**
 Ca2+ (mg/mg Cr)0.11 ± 0.01 (9)0.11 ± 0.014 (7)
 Mg2+ (mg/mg Cr)1.24 ± 0.09 (9)1.66 ± 0.21 (7)
 Creatinine (mg/dL)37.7 ± 6.26 (9)18.64 ± 2.25 (7)*
Urinary volume (mL)0.84 ± 0.11 (6)1.98 ± 0.10 (10)***
Creatinine clearance (mL/min)0.25 ± 0.07 (8)0.18 ± 0.06 (6)
Weight (g)25.94 ± 2.57 (19)25.32 ± 0.61 (13)
Food intake (g)3.07 ± 0.15 (9)3.32 ± 0.034 (7)
Water intake (mL)3.83 ± 0.64 (6)5.25 ± 0.43 (10)
  • Values are presented as the mean ± SE. The number of animals per group (n) is given in parentheses. *P < 0.05; **P < 0.005; ***P < 0.0005.