Table 2.

Toxicity profile in CD1 mice post i.v. injection of Wtmn formulations

Normal rangeWtmnNP Wtmn
1/5th MTD of Wtmn (0.14 mg/kg)
 Hematologic toxicity
  WBC3.5–10 (103/μL)2.8 ± 0.285.1 ± 0.42
  Granulocytes1.2–8 (103/μL)0.8 ± 0.142.9 ± 0.07
  Lymphocytes0.5–5 (103/μL)0.4 ± 0.423.56 ± 0.21
  Monocytes0.1–1.5 (103/μL)0.55 ± 0.070.7 ± 0.14
 Hepatotoxicity
  ALT U/L40–50 U/L134 ± 1782 ± 12
  AST U/L40–50 U/L44 ± 346 ± 7
1/10th MTD of Wtmn (0.07 mg/kg)
 Hematologic toxicity
  WBC3.5–10 (103/μL)4.3 ± 0.134.9 ± 0.20
  Granulocytes1.2–8 (103/μL)2.4 ± 0.113.7 ± 0.12
  Lymphocytes0.5–5 (103/μL)0.9 ± 0.281.05 ± 0.21
  Monocytes0.1–1.5 (103/μL)0.8 ± 0.420.5 ± 0.14
 Hepatotoxicity
  ALT U/L40–50 U/L64 ± 1160 ± 9
  AST U/L40–50 U/L40 ± 742 ± 10
  • Mice were treated with indicated doses of Wtmn or NP Wtmn containing an equivalent dose of Wtmn (2% wt/wt). Single tail-vein i.v. injection was given, and a toxicity profile was taken 24 h post injection. Full profile is in Table S1.