Table 1.

Acute effects of different antiepileptic drugs in hAPPJ20 mice

FDA-approved antiepileptic drugsAcute injection dose (mg/kg)Fraction of mice with >50% spike reductionChange in spikes relative to baseline (%)*Statistical significanceEffect
Ethosuximide4001/6−0.8 (± 18.9)P = 0.96None
Gabapentin1000/4−10.3 (± 12.1)P = 0.45None
Levetiracetam2007/7−70.6 (± 4.9)P < 0.0001Suppression
Phenytoin1000/3+183.2 (± 48.7)P = 0.043Exacerbation
Pregabalin2000/3+87.7 (± 14.6)P = 0.026Exacerbation
Valproic acid3000/4+20.3 (± 15.4)P = 0.28None
Vigabatrin3000/4+0.8 (± 15.6)P = 0.96None
  • *Over a period of 6 h postinjection.

  • One-sample t test compared to baseline.