Table 4.

Estradiol transport across full-thickness pig skin in presence of AvD and AvG (n = 9)

Donor compartmentPermeability × 10−3 , cm/hLag time, hEnhancement factor
Estradiol2.27 ± 0.484.96 ± 2.75NA
Estradiol + 1 mg/mL AvD4.29 ± 1.26*5.93 ± 2.381.93 ± 0.50
Estradiol + 1 mg/mL AvG4.19 ± 0.63*5.43 ± 2.051.89 ± 0.65
  • 3H estradiol (saturated solution in PBS with radioactive tracer) was used for the transport studies. The enhancement factor is a comparison measure within each experiment, and it is the ratio of the permeability of estradiol in presence of Avs to its native permeability across SC. The average ± SD is reported. Estradiol applied with AvD or AvG was significantly more permeable than estradiol applied alone. Differences in lag time were not significant. NA, not applicable.

  • *P < 0.1.