Table 5.

Transport of macromolecules across full-thickness pigskin in presence of Av D and AvG

Donor compartmentPermeability, cm/hEnhancement factor
Inulin2.21 ± 0.55 × 10−5NA
Inulin with 1 mg/mL AvD3.92 ± 0.89* × 10−51.77 ± 0.40
Inulin with 1 mg/mL AvG3.12 ± 0.43* × 10−51.41 ± 0.20
Dextran4.54 ± 0.67 × 10−5NA
Dextran with 1 mg/mL AvD7.50 ± 1.97* × 10−51.65 ± 0.43
Dextran with 1 mg/mL AvG6.46 ± 1.29* × 10−51.42 ± 0.28
PEG5.58 ± 0.53 × 10−6NA
PEG with 1 mg/mL AvD5.06 ± 0.24 × 10−60.91 ± 0.04
PEG with 1 mg/mL AvG5.29 ± 1.94 × 10−60.95 ± 0.35
  • The average ± SD is reported (n = 9). All macromolecules with AvD or AvG were tested for significance against baseline macromolecule transport. Significance is designated. NA, not applicable.

  • *P < 0.1