Table 1.

Passenger mutations in whole-genome sequences

Cancer(s)Protein-coding mutationsDriver mutations*Ref(s).
11 breast115.45.1(4)
10 colon754(4)
4 astrocytomas2065.5(52)
Acute myeloid leukemia102(53)
26 melanomas3664(1, 32)
Small-cell lung1004(2)
  • In most tumors, hundreds of protein-coding mutations accrue, yet only a few are putative drivers. These values are consistent with our model’s results. Deleterious passengers may be most exploitable in carcinomas, because leukemia and many blood cancers are generally more sensitive to DNA damage and have earlier incidence rates.

  • *Classified as drivers by COSMIC (8).