PK parameter | Values |

AUC_{[0-24} _{h]},^{*} h.ng/mL | 47,196 |

C_{max},^{*} ng/mL | 3,676 |

Central compartment (initial phase, t = 0) | |

V_{d}, mL/kg | 21.5 |

C_{L} at t = 0, mL/h | 3.5 |

t_{1/2}, h | 0.6 |

Periphery compartment (terminal phase, t = 24 h) | |

V_{d}, mL/kg | 9.9 |

C_{L}, terminal, mL/h | 0.03 |

t_{1/2}, h | 71.7 |

Least-square fit to model.

*C*=*a*× exp[(−*k*_{1}×*t*) +*b*× exp(−*k*_{2}×*t*)]. AUC, area under curve; C_{max}, Peak plasma concentration;*C*_{L}, total body clearance;*t*_{1/2}, plasma half-life;*V*_{d}, volume of distribution.↵* Model used to extrapolate concentrations at

*t*= 0.