Table 1.

Summary of parameters and outcomes of the PET/fMRI paradigm for putamen in two animals (M1 and M2)

Study parameters and outcomesDose 1Dose 2Dose 3Dose 4
Study parameters*
 Injected RAC mass, μg/kg0.30.34.54.516164040
 Specific activity, μCi/nmol1,3501,35053538.98.966
Study outcomesM1M2M1M2M1M2M1M2
BPND3.05.61.83.21.11.60.30.9
Graphic
3.35.11.62.40.81.10.20.6
 RAC occupancies
Graphic
, %
00404363719084
 Peak RAC occupancies
Graphic
, %
00505274779488
 Peak
Graphic
CBV, %
0.5 ± 0.3−1.1 ± 0.42.25.85.6107.312
  • * Average values from studies in two animals.

  • Occupancies are computed relative to dose 1.

  • Average CBV from repeated studies.