Table 3.

Telomerase gene variants in centenarians and controls

No. of Heterozygotes
Nucleotide changeProtein changeCentenarians (n = 100)Controls (n = 80)
hTERT
 Non-synonymous835 G > AAla 279 Thr01
3148 G > AAla 1050 Thr01
 Synonymous915 G > AAla 305 Ala4327
1812 A > GAla 604 Ala11
1849 C > TLeu 618 Leu11
2355 C > GSer 785 Ser10
2481 G > AThr 827 Thr30
2739 C > THis 913 His41
3097 C > THis 1013 His2811
 IntronicIVS1-211G > A20
IVS1-187 T > C5236
IVS4+10 C > T40
IVS4+21 C > T10
IVS16+64 C > T20
IVS16+99 C > T3012
hTERC
 IntronicIVS-99 C > G10
IVS+12 A > G10
IVS+63 T > C3027
  • Previously unknown unique variants are indicated in bold.