Table 3.

Plasma hypomethylation and CNA analyses for multiple types of cancers

Cancer typeCase no.Staging*/tumor max dimensionMethylation analysisCNA analysisClassification based on the “OR” algorithmClassification based on the “AND” algorithm
Percentage of bins with significant hypomethylation, %Percentage of bins with copy no. gains or losses, %
Breast cancerTBR150Metastatic30.336.9PositivePositive
TBR126T2N1M028.816.6PositivePositive
4.5 cm
TBR127T2N1M06.80.4PositiveNegative
2.5 cm
TBR128T2N0M00.322.5PositiveNegative
2 cm
TBR111T1N0M00.31.7PositiveNegative
0.9 cm
Smooth muscle sarcomaTBR051Metastatic7.559.4PositivePositive
Neuroendocrine tumorTBR052Metastatic10080.3PositivePositive
Lung cancerTBR164Metastatic94.637.8PositivePositive
TBR012Metastatic19.922.8PositivePositive
TBR014Metastatic5.96.8PositivePositive
TBR177T2N1M03.00.2PositiveNegative
3.9 cm
Nasopharyngeal cancerTBR031Metastatic6.115.3PositivePositive
TBR125Metastatic49.742.3PositivePositive
TBR124T4N10.00.5NegativeNegative
TBR123T1N2M020.80.8PositivePositive
TBR062T3N1M00.00.3NegativeNegative
TBR108T3N1M00.00.3NegativeNegative
TBR107T3N0M01.92.6PositivePositive
TBR106T1N1M02.61.2PositivePositive
TBR099T1N0M016.20.4PositiveNegative
  • * According to Union for International Cancer Control/AJCC 2010 Cancer Staging Manual, 7th Ed. (31).

  • For methylation and CNA analyses, a positive result would be scored if the percentages of bins showing hypomethylation and CNA were >1.1% and 0.68%, respectively.