Table 1.

Summary of histopathological findings in C9ORF72-positive ALS/FTD cases and controls

Region and caseCase informationRAN inclusions
Motor cortex
Spinal cord
  • —, no inclusions; +, occasional; ++, moderate; +++, numerous inclusions; *, variable staining from section to section; A/F, ALS/FTD; CON, control; DX, diagnosis; F, female; M, male; NA, not available; PMD, postmortem interval; W, white/Caucasian. The apparent differences in the frequencies of the various inclusions may reflect differences in protein conformation and epitope availability or differences in the affinities of these antibodies.