Table 3.

Comparison of TALENs and CRISPR-Cas9 system on targeting of the CCR5 locus

MethodHR efficiencyBiallelic targeting efficiencyNHEJ efficiency
TALEN (L538-R557)100%10%45%
CRISPR-Cas9100%33.3%25%
  • The comparison was conducted using the same parental clone, WT2-3. Twenty clones were analyzed by PCR for each experiment.