Table 1.

The association of CNA burden with the risk of BCR and metastasis

EventVariableInitial cohort*Contemporary cohort
PHR95% CIPHR95% CI
BCRCNA burden<0.0011.091.061.130.0081.051.011.09
BCRStratified CNA burden§0.0211.991.113.550.0013.861.738.64
MetastasisCNA burden<0.0011.101.041.15insufficient events
MetastasisStratified CNA burden§0.0522.470.996.15insufficient events
  • * Initial cohort total n = 168, BCR n = 46 (43 per 1,000 person-years), metastases n = 19 (15 per 1,000 person-years).

  • Contemporary cohort n = 104, BCR n = 24 (53 per 1,000 person-years), metastases n = 3 (5 per 1,000 person-years).

  • Per 1% change in CNA burden (continuous).

  • § The reference category is CNA burden ≤5.41% (mean of intermediate CNA clusters).