Table 1.

Expression of signature genes distinguishes BDL-aPFs from BDL- and CCl4-aHSCs

Maximum induction (up-regulation) in aPF (BDL, 20 d)Fold
Calcitonin α (Calca)66
Glycoprotein m6a (Gpm6a)35
Uroplakin 1β28
Basonuclin 1 (Bnc1)24
Mesothelin (msln)24
Frizzled-related protein 4 (Sfrp4)21
Cyp2s120
Proteoglycan 4 (Prg4)18
Asporin (aspn)18
Mucin 16 (Muc16)16
IL-18R114
Myosin light peptide7 (Myl7)14
Vitrin (Vit)12
Glipican 3 (Gpc3)12
CD20011
Apolipoprotein D (ApoD)10
IL-25R9.7
Dermokin (Dmkn)9.3
Vanin (Vnn1)8.5
Thrombospondin 4 (Thbs4)7.0
Integrin β4 (Itgb4)6.5
CD555.6
Gremlin 1 (Grem1)4.8
NTPD24.6
PDGFc4.6
Fibulin 2 (Fbln2)4.4
CD93.1
Elastin (Eln)2.3
Thy1 (CD90)1.8
Cytoglobin0.6
  • Using the whole mouse genome microarray, expression of signature genes was determined for BDL-aPFs. Expression of genes previously identified as PF-specific (underlined) was confirmed. Fold induction (compared with the highest value observed in BDL- or CCl4-aHSCs) is shown for each gene. Full list of genes is shown in Fig. S7.