Table 1.

Cumulative incidence of breast or ovarian cancer among women with mutations in BRCA1 or BRCA2, ascertained via unaffected males

To age, yBRCA1 (SE)BRCA2 (SE)
Risk of breast cancer
300.02 (0.02)0
400.17 (0.04)0.04 (0.03)
500.35 (0.06)0.09 (0.05)
600.41 (0.06)0.26 (0.08)
700.52 (0.08)0.32 (0.09)
800.60 (0.10)0.40 (0.11)
Risk of ovarian cancer
4000
500.05 (0.03)0.03 (0.03)
600.27 (0.07)0.07 (0.05)
700.47 (0.10)0.13 (0.07)
800.53 (0.11)0.62 (0.18)
Risk of either breast or ovarian cancer
300.03 (0.02)0
400.23 (0.05)0.04 (0.03)
500.41 (0.06)0.16 (0.06)
600.60 (0.07)0.33 (0.09)
700.77 (0.07)0.47 (0.11)
800.83 (0.07)0.76 (0.13)