Table 1.

Loss of righting reflex

Anesthetic used (no. of mice)LORR latencyLORR duration
Ketamine
 WT (12)160.8 ± 6.3889.2 ± 86.1
 KO (12)232.5 ± 12.9***581.7 ± 98.3**
Ethanol
 WT (9)76.0 ± 5.42670.0 ± 165.9
 KO (11)92.7 ± 3.8*1481.8 ± 165.4**
  • Latency and duration of LORR as a behavioral measure of unconsciousness.

  • * P < 0.05, **P < 0.01, ***P < 0.001; one-way ANOVA.