Table S1.

Secreted cytokine protein abundance in CM from control (CON), irradiation-induced senescent (SEN), and JAK inhibitor 1-treated senescent (SEN+JAKi) human preadipocytes

NameUnitCONSENSEN+JAKiP (C vs. S)P (S vs. S+J)
IL-6Nanograms per 106 cells9.1 ± 1.1176.9 ± 13.773.8 ± 10.80.0000.000
GM-CSFPicograms per 106 cells34.9 ± 6.3992.5 ± 172.2311.8 ± 57.40.0000.000
G-CSFPicograms per 106 cells40 ± 14389 ± 105147 ± 290.0000.001
IP-10Nanograms per 106 cells4.1 ± 1.416.7 ± 4.91.2 ± 0.30.0550.000
CXCL-1Nanograms per 106 cells3.1 ± 0.885.9 ± 15.945.6 ± 7.20.0000.002
MIP-1aPicograms per 106 cells36 ± 91,069 ± 40293 ± 330.0000.000
IL-8Nanograms per 106 cells2.2 ± 0.6105.6 ± 18.539.3 ± 4.90.0000.000
MCP-1Nanograms per 106 cells9.0 ± 2.6174.7 ± 40.272.1 ± 16.20.0000.000
RANTESNanograms per 106 cells1.88 ± 0.6929.02 ± 5.4813.88 ± 2.260.0000.000
MCP-3Picograms per 106 cells147 ± 452,534 ± 675719 ± 1370.0000.000
PAI-1Picograms per 106 cells35.2 ± 18.1111.2 ± 14.578.8 ± 12.80.0010.000
MIP-1bPicograms per 106 cells15.4 ± 5.853.6 ± 14.242.7 ± 11.20.0000.114
TNF-αPicograms per 106 cells5.7 ± 2.225.4 ± 4.016.5 ± 3.20.0010.011
IFN-α2Picograms per 106 cells43 ± 15413 ± 144319 ± 730.0000.203
IL-7Picograms per 106 cells12.2 ± 2.392.1 ± 24.488.7 ± 21.50.0000.594
IL-1αPicograms per 106 cells7.98 ± 2.2865.7 ± 10.546.0 ± 9.20.0000.039
IFN-γPicograms per 106 cells11.8 ± 2.6486.3 ± 20.084.3 ± 18.60.0000.923
IL-1RAPicograms per 106 cells64 ± 11401 ± 135303 ± 610.0000.429
FGF-2Picograms per 106 cells299 ± 1761,169 ± 5141,320 ± 6790.0000.498
IL-15Picograms per 106 cells10.3 ± 4.725.9 ± 2.525.4 ± 4.60.0000.987
EGFPicograms per 106 cells12.4 ± 3.163.1 ± 18.965.2 ± 20.30.0000.588
FractalkinePicograms per 106 cells381 ± 931,707 ± 3961733 ± 4510.0000.887
VEGFNanograms per 106 cells2.99 ± 1.859.37 ± 1.836.60 ± 1.710.0000.012
IL-12p40Picograms per 106 cells45.9 ± 17.01,74.0 ± 60.4174.1 ± 56.00.0000.525
IL-12p70Picograms per 106 cells8.9 ± 3.928.8 ± 5.633.3 ± 8.80.0000.344
IL-1βPicograms per 106 cells6.1 ± 3.419.0 ± 5.312.7 ± 2.30.0000.711
TNF-βPicograms per 106 cells6.7 ± 2.619.9 ± 8.915.7 ± 2.80.0010.345
MDCPicograms per 106 cells276 ± 127595 ± 136680 ± 1750.0010.369
CCL-11Picograms per 106 cells478 ± 1861,411 ± 355796 ± 1350.1660.009
PDGF-BBPicograms per 106 cells12.7 ± 6.321.4 ± 1.320.1 ± 3.90.3980.916
PDGF-AAPicograms per 106 cells43.1 ± 24.6125.2 ± 61.856.4 ± 17.50.8060.002
  • All values are shown as mean ± SEM; n = 6. CCL-11, eotaxin; fractalkine, CX3CL-1; IL-1RA, interleukin 1 receptor antagonist; MDC (CCL-22), macrophage-derived chemokine; P (C vs. S), P value for difference between control and senescent cells; P (S vs. S+J), P value for difference between vehicle- and JAK inhibitor 1-treated senescent cells.