Table 1.

Particles, tetrads, and functionality statistics

TypeNo. of particles per tetrad siteNo. of complete tetrads per tetrad siteJunctional T tubule/total T-tubule lengthQmax, nC/μFΔF/FmaxΔF/F V1/2, mVKF, mV
WT3.40 ± 0.52 (n = 84)0.62 ± 0.360.65 ± 0.13 (n = 42)8.43.87 ± 0.37−14.6 ± 2.36.2 ± 0.5
WT rescue3.04 ± 0.70** (n = 72)0.45 ± 0.31*0.68 ± 0.13** (n = 40)9.5*2.30 ± 0.21*−21.2 ± 1.8*7.2 ± 0.8
NAM rescue2.76 ± 0.44**,ns (n = 43)0.23 ± 0.25*,ns0.44 ± 0.13**,ns (n = 38)0.9*,ns0.28 ± 0.04*,nd−2.3 ± 6.3*,nd17.2 ± 2.8*,nd
stac3−/−2.52 ± 0.54** (n = 31)0.23 ± 0.41**0.42 ± 0.14** (n = 31)1.1*0*ndnd
stac3−/− MO2.37 ± 0.44ns (n = 35)0.08 ± 0.14#0.26 ± 0.14# (n = 28)ndndndnd
  • Tukey post hoc comparisons: WT rescue vs. stac3−/−. NAM rescue vs. WT rescue (first P value) and NAM rescue vs. stac3−/− (second P value). stac3−/− vs. WT. ANOVA, **P < 0.001, *P < 0.01. t test was used for stac3−/− MO vs. stac3−/−. #t test, P < 0.05. nd, not determined.