Table S1.

Summary of the 26 SAMHD1 mutations present in 24 large intestine tumors from COSMIC

AA substitutionGranthamSIFTPolyPhenCADDConSurf
F59C*205DeleteriousProbably damaging11.683
A76T58ToleratedBenign6.6035
L78LSilentSilentSilent7.7748
L132I5DeleteriousPossibly damaging27.98
V133I (×2)29ToleratedBenign15.157
R145Q43DeleteriousProbably damaging349
D207Y160DeleteriousProbably damaging20.89
R226H29ToleratedPossibly damaging28.86
T232M81DeleteriousPossibly damaging24.57
S247Y*144DeleteriousBenign24.15
K288T*78ToleratedBenign22.93
S302Y144DeleteriousBenign258
R305I97ToleratedBenign23.77
A338T58DeleteriousPossibly damaging29.38
A338V64ToleratedBenign22.98
R348C180ToleratedBenign23.16
R366H29DeleteriousPossibly damaging349
R451P103DeleteriousProbably damaging28.19
D497Y160DeleteriousBenign24.57
D501Y160DeleteriousBenign26.24
A525T58DeleteriousBenign8.325
F578V50DeleteriousBenign13.095
P581PSilentSilentSilent7.2637
K596fs (×2)fsfsfsfsfs
  • Results are shown from four effect-prediction software programs (Grantham, SIFT, PolyPhen, and CADD) and one conservation analysis software program (ConSurf). The eight mutations originating from the TCGA dataset, hgsc.bcm.edu COAD.IlluminaGA DNASeq.Level 2.1.5.0, are indicated in bold. For Grantham, >60 is nonconservative; for CADD, >15 is damaging; and for ConSurf, 9 is most conserved. fs, frame shift; ×2, the same variant was found in two independent tumors.

  • * All in one individual.