Table 1.

Changes per year in the thickness of the parafoveal and perifoveal rings of the retinal NFL and GCL+IPL in patients with type 1 DM with no or minimal DR

Independent variableParafoveal NFLPerifoveal NFLParafoveal GCL+IPLPerifoveal GCL+IPL
Intercept15.05 μm, P < 0.001 (95% CI, 10.05–20.05 μm)38.72 μm, P < 0.001 (95% CI, 32.68–44.76 μm)104.18 μm, P < 0.001 (95% CI, 93.58–114.78 μm)71.21 μm, P < 0.001 (95% CI, 65.40–77.03μm )
Female sex−1.79 μm, P = 0.008 (95% CI, −3.10 to −0.48 μm)−0.27 μm, P = 0.739 (95% CI, −1.84 to 1.31 μm)−4.22 μm, P = 0.012 (95% CI, −7.49 to −0.95 μm)0.11 μm, P = 0.896 (95% CI, −1.50 to 1.71 μm)
Age at inclusion, y0.08 μm, P = 0.135 (95% CI, −0.02 to 0.15 μm)−0.02 μm, P = 0.612 (95% CI, −0.13 to 0.08 μm)0.04 μm, P = 0.786 (95% CI, −0.19 to 0.27μm )−0.06 μm, P = 0.374 (95% CI, −0.15 to 0.06 μm)
Duration prior DM, y−0.19 μm, P = 0.002 (95% CI, −0.30 to −0.08 μm)−0.21 μm, P = 0.005 (95% CI, −0.34 to −0.06 μm)0.44 μm, P = 0.004 (95% CI, -0.74 to −0.13)−0.11 μm, P = 0.120 (95% CI, −0.27 to 0.04 μm)
Follow-up, y−0.25 μm, P < 0.001 (95% CI, −0.40 to −0.11 μm)−0.25 μm, P = 0.004 (95% CI, −0.42 to −0.08 μm)0.29 μm, P = 0.006 (95% CI, −0.49 to −0.08 μm)0.19 μm, P = 0.021 (95% CI, 0.04–0.36 μm)
Minimal DR at inclusion, present/absent1.03 μm, P = 0.203 (95% CI, −0.55 to 2.60 μm)−0.19 μm, P = 0.838 (95% CI, −2.09 to 1.69 μm)1.71 μm, P = 0.361 (95% CI, −1.98 to 5.38 μm)0.17 μm, P = 0.864 (95% CI, −1.73 to 2.05 μm)
DR grade0.06 μm, P = 0.815 (95% CI, −0.48 to 0.61 μm)0.06 μm, P = 0.855 (95% CI, −0.59 to 0.70 μm)−0.63 μm, P = 0.147 (95% CI, −1.48 to 0.23 μm)−0.32 μm, P = 0.283 (95% CI, −0.93 to 0.29 μm)
HbA1c, %0.13 μm, P = 0.432 (95% CI, −0.19 to 0.46 μm)−0.40 μm, P = 0.048 (95% CI, μm 0.80 to −0.00 μm)0.06 μm, P = 0.811 (95% CI, −0.42 to 0.53μm )0.17 μm, P = 0.366 (95% CI, −0.19 to 0.51 μm)
  • Shown are the change in thickness per year (in micrometers) per one unit change of each independent variable, the P value, and the 95% CI. Significant changes are shown in boldface type. Blood pressure and DR progression were not significantly associated.