Table S3.

Enrichment GO for biological process showing the most significant terms that are altered among the 205 genes that confer responsiveness to LAC oral treatment

GO IDTermNo. of genesOver(+)/under(−)P value after Bonferroni−log10(P value)
GO:0009888Tissue development56+4.38E-109.36
GO:0044260Cellular macromolecule metabolic process257.82E-087.11
GO:0042060Wound healing22+5.93E-076.23
GO:0048513Organ development72+1.09E-065.96
GO:0009611Response to wounding25+1.51E-065.82
GO:0044237Cellular metabolic process461.30E-054.89
GO:0048545Response to steroid hormone28+3.35E-054.47
GO:0048732Gland development23+2.01E-043.70
GO:0009887Organ morphogenesis30+3.41E-043.47
GO:0034641Cellular nitrogen compound metabolic process165.81E-043.24
GO:0001568Blood vessel development21+6.99E-043.16
GO:0033993Response to lipid34+8.79E-043.06
GO:0060429Epithelium development32+9.31E-043.03
GO:0044267Cellular protein metabolic process151.18E-032.93
GO:0043627Response to estrogen18+1.33E-032.88
GO:0001944Vasculature development21+2.09E-032.68
GO:0001655Urogenital system development18+2.94E-032.53
GO:0006807Nitrogen compound metabolic process203.05E-032.52
GO:0042476Odontogenesis10+3.17E-032.50
GO:0014070Response to organic cyclic compound35+4.21E-032.38
GO:0010467Gene expression84.44E-032.35
GO:0022612Gland morphogenesis11+4.54E-032.34
GO:0043170Macromolecule metabolic process415.83E-032.23
GO:0044238Primary metabolic process547.20E-032.14
GO:0072359Circulatory system development28+7.49E-032.13
GO:0072358Cardiovascular system development28+7.49E-032.13
GO:1901342Regulation of vasculature development13+7.86E-032.10
GO:0048608Reproductive structure development19+9.57E-032.02
GO:0046483Heterocycle metabolic process141.02E-021.99
GO:0006139Nucleobase-containing compound metabolic process131.18E-021.93
GO:0061458Reproductive system development19+1.19E-021.92
GO:0048731System development77+1.40E-021.85
GO:0048771Tissue remodeling10+1.52E-021.82
GO:0045765Regulation of angiogenesis12+1.63E-021.79
GO:0009725Response to hormone32+1.77E-021.75
GO:0030335Positive regulation of cell migration17+1.89E-021.72
GO:0061448Connective tissue development13+2.13E-021.67
GO:0030334Regulation of cell migration23+2.23E-021.65
GO:0048729Tissue morphogenesis22+2.24E-021.65
GO:0071704Organic substance metabolic process592.45E-021.61
GO:0044707Single-multicellular organism process92+2.56E-021.59
GO:2000147Positive regulation of cell motility17+2.65E-021.58
GO:0097305Response to alcohol21+2.74E-021.56
GO:0007275Multicellular organismal development81+2.80E-021.55
GO:0018149Peptide cross-linking5+2.82E-021.55
GO:0051270Regulation of cellular component movement25+3.01E-021.52
GO:0051272Positive regulation of cellular component movement17+3.89E-021.41
GO:2000145Regulation of cell motility23+4.56E-021.34
GO:0040017Positive regulation of locomotion17+4.80E-021.32
  • Over, overrepresented; under, underrepresented.