Table S3.

Estimates from separate regressions of rLRS on the polygenic score of each phenotype, for the study sample and for each cohort separately, and by sex and for females and males together

ScoreStudy sample (born 1931–1953)HRS1 cohort (born 1931–1941)HRS2 cohort (born 1942–1947)HRS3 cohort (born 1948–1953)
Females
Score of BMI0.006 (0.010)0.017 (0.014)0.004 (0.020)−0.034 (0.025)
Score of EA−0.033*** (0.010)−0.038*** (0.014)−0.044** (0.020)−0.001 (0.025)
Score of GLU0.009 (0.010)0.002 (0.014)0.029 (0.021)0.004 (0.024)
Score of HGT−0.011 (0.014)−0.025 (0.019)0.024 (0.028)−0.019 (0.033)
Score of SCZ−0.001 (0.011)−0.012 (0.015)0.053** (0.022)−0.035 (0.025)
Score of TC−0.012 (0.011)−0.022 (0.014)−0.005 (0.021)0.010 (0.025)
Score of AAM0.018* (0.011)0.008 (0.014)0.021 (0.021)0.037 (0.024)
N3,4161,840811765
Males
Score of BMI0.016 (0.013)0.015 (0.016)−0.025 (0.029)0.049 (0.032)
Score of EA−0.031** (0.012)−0.050*** (0.015)−0.010 (0.028)0.012 (0.031)
Score of GLU−0.013 (0.013)0.009 (0.016)−0.023 (0.028)−0.051* (0.031)
Score of HGT−0.005 (0.018)0.016 (0.022)−0.043 (0.040)−0.024 (0.042)
Score of SCZ0.009 (0.013)0.033** (0.016)−0.033 (0.032)−0.009 (0.033)
Score of TC−0.003 (0.013)−0.010 (0.016)0.010 (0.030)0.022 (0.033)
N2,5711,493506572
Females and males together (one person per household)
Score of BMI0.018* (0.010)0.025** (0.012)0.013 (0.018)−0.014 (0.022)
Score of EA−0.041*** (0.009)−0.047*** (0.012)−0.039** (0.018)−0.008 (0.021)
Score of GLU−0.003 (0.009)0.011 (0.012)0.006 (0.018)−0.037* (0.021)
Score of HGT−0.015 (0.013)−0.008 (0.016)0.001 (0.026)−0.011 (0.028)
Score of SCZ0.011 (0.010)0.011 (0.013)−0.016 (0.020)−0.004 (0.022)
Score of TC−0.008 (0.010)−0.012 (0.012)−0.005 (0.019)0.007 (0.022)
N4,3612,6471,1351,121
  • This table mirrors Table 2 but also shows the results for each cohort separately as well as for females and males together (the results for the study sample for females and for males separately are the same as those shown in Table 2). The table shows estimates of the coefficients on the polygenic scores and their SEs (in parentheses) from separate regressions of rLRS on the polygenic score of each phenotype. Each estimate comes from a different regression. All regressions included birth year dummies, HRS-defined cohort dummies, and the top 20 principal components of the genetic relatedness matrix, and all regressions for a cohort and sex had the same number of observations. The regressions for females and males together also included a sex dummy and only included the respondent with the lowest PN in each household. (The results for the score of EA are robust to alternative ways of selecting one respondent per household, but the significant estimates for the score of BMI are not.) The coefficients can be interpreted as directional selection differentials of the scores, expressed in Haldanes—i.e., each coefficient equals the implied change in the score that will occur due to natural selection in one generation, expressed in SDs of the score. (*P < 0.10; **P < 0.05; ***P < 0.01.)