Table S7.

Estimates from separate regressions of rLRS on each phenotypic variable and on the polygenic score of each phenotype, for the HRS0 cohort (born 1924–1930)

VariableRegressions of rLRS on the phenotypic variablesRegressions of rLRS on the scores, genotyped individuals only
All individuals (genotyped and not genotyped)Genotyped individuals only
Coefficient estimateNCoefficient estimateNScoreCoefficient estimateN
Females
BMI0.015*** (0.003)1,7310.008* (0.005)766Score of BMI−0.020 (0.023)766
EA−0.013** (0.006)1,7360.008 (0.009)766Score of EA0.031 (0.023)766
Score of GLU−0.044* (0.023)766
HGT−0.000 (0.003)1,735−0.001 (0.004)766Score of HGT−0.046 (0.031)766
Score of SCZ0.006 (0.025)766
TC−0.024 (0.122)93Score of TC0.020 (0.023)766
Score of AAM−0.010 (0.024)766
Males
BMI0.003 (0.004)1,5620.007 (0.006)602Score of BMI0.002 (0.026)602
EA−0.003 (0.005)1,561−0.001 (0.008)602Score of EA0.029 (0.026)602
Score of GLU0.044* (0.026)602
HGT−0.003 (0.002)1,562−0.004 (0.004)602Score of HGT0.054 (0.034)602
Score of SCZ0.037 (0.026)602
TC−0.067 (0.059)590−0.102 (0.091)220Score of TC−0.026 (0.025)602
  • This table mirrors Table S2, but shows results for the HRS0 cohort. “Regression of rLRS on the phenotypic variables” shows estimates of the coefficients on the phenotypic variables and their SEs (in parentheses) from separate regressions of rLRS on each phenotypic variable. Each estimate comes from a different regression, and every regression included birth year dummies and HRS-defined cohort dummies. The HRS does not contain phenotypic variables for GLU, AAM, and SCZ; the results are not reported for TC for genotyped females because there are only 36 genotyped females with TC data in the HRS0 cohort. “Regression of rLRS on the scores” shows estimates of the coefficients on the polygenic scores and their SEs (in parentheses) from separate regressions of rLRS on the polygenic score of each phenotype. Each estimate comes from a different regression. All regressions include birth year dummies, HRS-defined cohort dummies, and the top 20 principal components of the genetic relatedness matrix. The coefficients can be interpreted as directional selection differentials of the scores, expressed in Haldanes—i.e., each coefficient equals the implied change in the score that will occur due to natural selection in one generation, expressed in SDs of the score. (*P < 0.10; **P < 0.05; ***P < 0.01.)