Variable | Regressions of rLRS on the phenotypic variables | Regressions of rLRS on the scores, genotyped individuals only | |||||

All individuals (genotyped and not genotyped) | Genotyped individuals only | ||||||

Coefficient estimate | N | Coefficient estimate | N | Score | Coefficient estimate | N | |

Females | |||||||

BMI | 0.015*** (0.003) | 1,731 | 0.008* (0.005) | 766 | Score of BMI | −0.020 (0.023) | 766 |

EA | −0.013** (0.006) | 1,736 | 0.008 (0.009) | 766 | Score of EA | 0.031 (0.023) | 766 |

Score of GLU | −0.044* (0.023) | 766 | |||||

HGT | −0.000 (0.003) | 1,735 | −0.001 (0.004) | 766 | Score of HGT | −0.046 (0.031) | 766 |

Score of SCZ | 0.006 (0.025) | 766 | |||||

TC | −0.024 (0.122) | 93 | — | — | Score of TC | 0.020 (0.023) | 766 |

Score of AAM | −0.010 (0.024) | 766 | |||||

Males | |||||||

BMI | 0.003 (0.004) | 1,562 | 0.007 (0.006) | 602 | Score of BMI | 0.002 (0.026) | 602 |

EA | −0.003 (0.005) | 1,561 | −0.001 (0.008) | 602 | Score of EA | 0.029 (0.026) | 602 |

Score of GLU | 0.044* (0.026) | 602 | |||||

HGT | −0.003 (0.002) | 1,562 | −0.004 (0.004) | 602 | Score of HGT | 0.054 (0.034) | 602 |

Score of SCZ | 0.037 (0.026) | 602 | |||||

TC | −0.067 (0.059) | 590 | −0.102 (0.091) | 220 | Score of TC | −0.026 (0.025) | 602 |

This table mirrors Table S2, but shows results for the HRS0 cohort. “Regression of rLRS on the phenotypic variables” shows estimates of the coefficients on the phenotypic variables and their SEs (in parentheses) from separate regressions of rLRS on each phenotypic variable. Each estimate comes from a different regression, and every regression included birth year dummies and HRS-defined cohort dummies. The HRS does not contain phenotypic variables for GLU, AAM, and SCZ; the results are not reported for TC for genotyped females because there are only 36 genotyped females with TC data in the HRS0 cohort. “Regression of rLRS on the scores” shows estimates of the coefficients on the polygenic scores and their SEs (in parentheses) from separate regressions of rLRS on the polygenic score of each phenotype. Each estimate comes from a different regression. All regressions include birth year dummies, HRS-defined cohort dummies, and the top 20 principal components of the genetic relatedness matrix. The coefficients can be interpreted as directional selection differentials of the scores, expressed in Haldanes—i.e., each coefficient equals the implied change in the score that will occur due to natural selection in one generation, expressed in SDs of the score. (*

*P*< 0.10; ***P*< 0.05; ****P*< 0.01.)