Table 1.

Pharmacokinetic parameters for chronically dosed clinically bioequivalent RIF, ABZ, and RIF+ABZ

ParameterABZ monotherapy (n = 8)ABZ combination therapy (n = 5)RIF monotherapy (n = 3)RIF combination therapy (n = 5)
CL/F, mL/(h⋅kg)868 ± 323724 ± 256167 ± 4156 ± 80
V/F, mL/kg2,187 ± 8462,572 ± 6941,871 ± 3143,857 ± 1,167
ka4.27.81.0 ± 0.52.4 ± 0.7
AUC24 h—day 5, µg⋅h/mL7.7 ± 5.28.9 ± 4.246.7 ± 16.030.0 ± 11.5
  • AUC24 h—day 5, 24-hour exposure for day 5; CL/F, apparent clearance; ka, rate constant for absorption; V/F, apparent volume of distribution.