Table S5.

Statistical comparison of the percent of directed vaccine effect for anatomical locations indicated in Fig. 3B

Day	Mean diff.	95% CI of diff.	Significant
Nasopharynx
1	30	24.02–35.98	Yes
2	31	25.02–36.98	Yes
3	56	50.02–61.98	Yes
4	96	90.02–102	Yes
5	84	78.02–89.98	Yes
6	83	77.02–88.98	Yes
7	61	55.02–66.98	Yes
8	94	88.02–99.98	Yes
9	104	98.02–110	Yes
10	43	37.02–48.98	Yes
11	75	69.02–80.98	Yes
12	71	65.02–76.98	Yes
13	60	54.02–65.98	Yes
14	66	60.02–71.98	Yes
Nasopharynx lavage
1	98	92.02–104	Yes
2	135	129–141	Yes
3	64	58.02–69.98	Yes
4	43	37.02–48.98	Yes
5	96	90.02–102	Yes
6	112	106–118	Yes
7	100	94.02–106	Yes
8	83	77.02–88.98	Yes
9	40	34.02–45.98	Yes
10	25	19.02–30.98	Yes
11	61	55.02–66.98	Yes
12	50	44.02–55.98	Yes
13	33	27.02–38.98	Yes
14	41	35.02–46.98	Yes
Lung
1	−22	−27.98 to −16.02	Yes
2	33	27.02–38.98	Yes
3	52	46.02–57.98	Yes
4	37	31.02–42.98	Yes
5	26	20.02–31.98	Yes
6	59	53.02–64.98	Yes
7	54	48.02–59.98	Yes
8	59	53.02–64.98	Yes
9	58	52.02–63.98	Yes
10	49	43.02–54.98	Yes
11	47	41.02–52.98	Yes
12	54	48.02–59.98	Yes
13	77	71.02–82.98	Yes
14	65	59.02–70.98	Yes

CI, confidence interval; Mean Diff., mean difference between planktonic and biofilm-released values. All adjusted P values <0.0001.