Table 2.

Results from Cox proportional hazard models predicting parental mortality risk from offspring education polygenic profile score

ParentCohortn Offspringn Parental deathsHR (95% CI)SEP value
MotherGeneration Scotland16,6706,3300.954 (0.907, 1.001)0.0240.056
UK Biobank115,32369,9900.976 (0.968, 0.984)0.0041.52 × 10−10
Estonian Biobank5,9292,6820.979 (0.940, 1.018)0.0200.280
Meta-analysis137,92279,7020.976 (0.968, 0.983)0.0048.21 × 10−10
FatherGeneration Scotland16,3908,4670.932 (0.891, 0.973)0.0210.0007
UK Biobank111,33485,4190.975 (0.969, 0.981)0.0032.05 × 10−13
Estonian Biobank6,0973,7440.942 (0.909, 0.975)0.0170.0003
Meta-analysis133,82197,6300.973 (0.967, 0.979)0.0041.73 × 10−18
  • Hazard ratios are expressed per SD of polygenic profile score. Meta-analytic rows are in bold. All models adjusted for offspring sex, genotyping array, and SNP principal components as described in Materials and Methods.