Table 1.

Summary of experimental findings at human nAChRs

Peptideα4β2 nAChRIC50 at additional nAChRs, μM
ToxDock predictionIC50, μMα7α3β2α3β4
α-GID30.10.01>10
α-GID[A10V]Bioactive30>100.003>10
α-GID[A10Q]Inactive>200>10>10>10
α-GID[V13I]Bioactive80.20.001>10
α-GID[V13Y]Bioactive340.002>10