Table 2.

Altered RCL sequences for selective cleavage by targeted proteinases

Targeted proteinaseRCL sequence*
P6P5P4P3P2P1P1′P2′P3′
α-ChymotrypsinVKITLLSAL
HRV3CPLEVLFQGPL
MMP9LKGPRQITA
MMP14LFIPLSLRM
  • * P-nomenclature according to Schechter and Berger (17).

  • Proteinase-specific cleavage sites as described previously (3234).