Table 1.

Differentially regulated genes in islets from chow-fed WT and R138X mice

Gene IDSymbolFold changeP valueDescription
170942Erdr13.349.80E-04Erythroid differentiation regulator 1
74096Hvcn12.873.90E-03Hydrogen voltage-gated channel 1
12483Cd222.792.70E-03CD22 antigen
19354Rac22.636.60E-04RAS-related C3 botulinum substrate 2
12265Ciita2.472.50E-03Class II transactivator
17691Sik12.377.10E-08Salt-inducible kinase 1
18636Cfp2.017.50E-03Complement factor properdin
17318Mid11.791.70E-03Midline 1
170935Grid2ip1.758.60E-03Glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
666048Trabd2b1.724.20E-03TraB domain-containing 2B
11899Astn11.671.60E-03Astrotactin 1
23984Pde10a1.664.50E-03Phosphodiesterase 10A
244723Olfm21.627.40E-03Olfactomedin 2
17294Mest1.608.30E-04Mesoderm specific transcript
319504Nrcam1.566.10E-06Neuron-glia-CAM-related cell adhesion molecule
104601Mycbpap1.533.80E-03MYCBP associated protein
12545Cdc71.538.00E-03Cell division cycle 7 (Saccharomyces cerevisiae)
544817Arhgap271.523.50E-03Rho GTPase activating protein 27
319760D130020L05Rik−1.521.10E-03RIKEN cDNA D130020L05 gene
195531Gm13152−1.543.40E-03Predicted gene 13152
66091Ndufa3−1.541.20E-03NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3
16334Ins2−1.547.20E-03Insulin II
235043Tmem205−1.548.70E-03Transmembrane protein 205
14470Rabac1−1.562.90E-03Rab acceptor 1 (prenylated)
14776Gpx2−1.591.80E-07Glutathione peroxidase 2
66416Ndufa7−1.596.20E-03NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
228715Gm561−1.596.90E-03Predicted gene 561
66845Mrpl33−1.592.10E-03Mitochondrial ribosomal protein L33
17178Fxyd3−1.593.10E-03FXYD domain-containing ion transport regulator 3
20832Ssr4−1.596.40E-03Signal sequence receptor, delta
66594Uqcr11−1.617.50E-03Ubiquinol-cytochrome c reductase, complex III subunit XI
66152Uqcr10−1.617.30E-03Ubiquinol-cytochrome c reductase, complex III subunit X
67267Uqcc2−1.617.60E-03Ubiquinol-cytochrome c reductase complex assembly factor 2
69038Tmem258−1.614.60E-03Transmembrane protein 258
678851500011K16Rik−1.619.30E-03RIKEN cDNA 1500011K16 gene
100502825Rpl37rt−1.615.40E-03Predicted gene 13826
661171110001J03Rik−1.614.40E-03RIKEN cDNA 1110001J03 gene
69094Tmem160−1.618.50E-03Transmembrane protein 160
67941Rps27l−1.614.00E-03Ribosomal protein S27-like
234421Cib3−1.645.30E-03Calcium and integrin binding family member 3
11807Apoa2−1.673.80E-04Apolipoprotein A-II
20892Stra13−1.672.90E-03Stimulated by retinoic acid 13
66477Usmg5−1.675.60E-03Up-regulated during skeletal muscle growth 5
68563Dpm3−1.672.50E-03Dolichyl-phosphate mannosyltransferase polypeptide 3
22177Tyrobp−1.679.90E-03TYRO protein tyrosine kinase binding protein
69386Hist1h4h−1.695.00E-03Histone cluster 1, H4h
268686S100z−1.699.90E-04S100 calcium binding protein, zeta
73720Cst6−1.692.80E-03Cystatin E/M
27425Atp5l−1.694.90E-03ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G
68194Ndufb4−1.724.70E-03NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
449000Zfp960−1.721.30E-03Zinc finger protein 960
93757Immp2l−1.753.20E-03IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
19735Rgs2−1.827.40E-03Regulator of G protein signaling 2
17873Gadd45b−1.821.40E-04Growth arrest and DNA-damage-inducible 45 beta
20335Sec61g−1.823.20E-03SEC61, gamma subunit
13190Dct−1.894.10E-04Dopachrome tautomerase
11811Apobec2−1.893.30E-03Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
100169864SlcUbl4a−2.132.90E-05Slc10a3-Ubl4 read-through
19782Rmrp−2.178.40E-03RNA component of mitochondrial RNase P
100568459Bc1−2.274.10E-03Brain cytoplasmic RNA 1
239436Slc30a8−6.671.40E-43Solute carrier family 30 (zinc transporter), member 8
  • Mitochondrial genes are marked in bold.