Table 1.

Tumor-like growth found in different organs of mice exposed to FA, Veh, and ECS*

No. of mice with tumor
Treatment (n = total mice receiving treatment)
OrgansFA (n = 18)Veh (n = 18)ECS (n = 40)
Abdominal Cavity#012
Liver, heart, brain, spleen, and kidney000
  • * Exposure conditions are described in the main text.

  • A single lung adenocarcinoma tumor was found in 8 ECS-exposed mice and 1 FA-exposed mouse. Multiple lung adenocarcinomas were found in 1 ECS-exposed mouse (Fig. 1).

  • Eight of 9 lung tumors were further identified by H & E staining and examined microscopically (Fig. 1). One lung tumor was inadvertently misplaced during the sample preparation.

  • § Hyperplasia was found in Veh-exposed (1 of 16) and ECS-exposed (23 of 40) mice. H & E and immunohistological staining results are presented in Fig. 2.

  • Adenomatous polyps with high-grade dysplasia were found in 1 FA-exposed mouse, 1 Veh-exposed mouse, and 1 ECS-exposed mouse.

  • # A single cystic salivary benign tumor was found in 1 Veh-exposed mouse and 1 ECS-exposed mouse. One benign epidermal inclusion cyst was found in 1 ECS-exposed mouse.

  • The tumor-like growth in the skin of the Veh-exposed mouse was necrotic tissue and cannot be further characterized; in the ECS-exposed mouse, it was identified as skin with muscle and a small piece of bone and was negative for tumor.