Table S2.

Kinetic data of lesion bypass by RNA pol II: Extension

LesionExtension
RNA primerkpol, min−1Kd, µMkpol/Kd, min−1⋅µM−1
O2-EtdT11A4.1 ± 0.11,600 ± 1000.0026 ± 0.0001
11U7.1 ± 0.84,600 ± 7000.0015 ± 0.0003
11G0.0014 ± 0.0001700 ± 70(1.9 ± 0.2) × 10−6
11C27 ± 410,000 ± 2,0000.0026 ± 0.0006
N3-EtdT11A0.13 ± 0.011,600 ± 200(8.1 ± 0.8) × 10−5
11U1.2 ± 0.14,600 ± 700(2.7 ± 0.5) × 10−4
11G0.0042 ± 0.0001800 ± 80(5.0 ± 0.5) × 10−6
11C2.9 ± 0.73,200 ± 1,100(9.1 ± 3.8) × 10−4
O4-EtdT11A12 ± 14,300 ± 7000.0027 ± 0.0005
11U34 ± 1470 ± 300.072 ± 0.005
11G87 ± 838 ± 202.3 ± 1.2
11C0.95 ± 0.164,800 ± 1,200(2.0 ± 0.6) × 10−4