affinity

You have access
High integrin α_Vβ₆ affinity reached by hybrid domain deletion slows ligand-binding on-rate
Xianchi Dong, Bo Zhao, Fu-Yang Lin, Chafen Lu, Bruce N. Rogers, and Timothy A. Springer

PNAS February 13, 2018 115 (7) E1429-E1436; published ahead of print January 29, 2018. https://doi.org/10.1073/pnas.1718662115
You have access
Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor
Yinglong Miao, Dahlia Anne Goldfeld, Ee Von Moo, Patrick M. Sexton, Arthur Christopoulos, J. Andrew McCammon, and Celine Valant

PNAS September 20, 2016 113 (38) E5675-E5684; published ahead of print September 6, 2016. https://doi.org/10.1073/pnas.1612353113
You have access
Optimal T-cell receptor affinity for inducing autoimmunity
Sabrina Koehli, Dieter Naeher, Virginie Galati-Fournier, Dietmar Zehn, and Ed Palmer

PNAS December 2, 2014 111 (48) 17248-17253; published ahead of print November 19, 2014. https://doi.org/10.1073/pnas.1402724111
You have access
Fast on-rates allow short dwell time ligands to activate T cells
Christopher C. Govern, Michelle K. Paczosa, Arup K. Chakraborty, and Eric S. Huseby

PNAS May 11, 2010 107 (19) 8724-8729; https://doi.org/10.1073/pnas.1000966107

Main menu