New Research In

antiviral

Open Access
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Matthew Mahoney, Vishnu C. Damalanka, Michael A. Tartell, Dong hee Chung, André Luiz Lourenço, Dustin Pwee, Anne E. Mayer Bridwell, Markus Hoffmann, Jorine Voss, Partha Karmakar, Nurit P. Azouz, Andrea M. Klingler, Paul W. Rothlauf, Cassandra E. Thompson, Melody Lee, Lidija Klampfer, Christina L. Stallings, Marc E. Rothenberg, Stefan Pöhlmann, Sean P. J. Whelan, Anthony J. O’Donoghue, Charles S. Craik, and James W. Janetka

PNAS October 26, 2021 118 (43) e2108728118; https://doi.org/10.1073/pnas.2108728118
Open Access
DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M^pro inhibitors
Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Kurt M. Bohren, Ying-Chu Chen, Huang-Chi Du, John C. Faver, Ravikumar Jimmidi, Feng Li, Jian-Yuan Li, Pranavanand Nyshadham, Stephen S. Palmer, Jeroen Pollet, Xuan Qin, Shannon E. Ronca, Banumathi Sankaran, Kiran L. Sharma, Zhi Tan, Leroy Versteeg, Zhifeng Yu, Martin M. Matzuk, Timothy Palzkill, and Damian W. Young

PNAS September 7, 2021 118 (36) e2111172118; https://doi.org/10.1073/pnas.2111172118
Open Access
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
Chamandi S. Dampalla, Jian Zheng, Krishani Dinali Perera, Lok-Yin Roy Wong, David K. Meyerholz, Harry Nhat Nguyen, Maithri M. Kashipathy, Kevin P. Battaile, Scott Lovell, Yunjeong Kim, Stanley Perlman, William C. Groutas, and Kyeong-Ok Chang

PNAS July 20, 2021 118 (29) e2101555118; https://doi.org/10.1073/pnas.2101555118
You have access
Cellular nucleic acid–binding protein is essential for type I interferon–mediated immunity to RNA virus infection
Yongzhi Chen, Xuqiu Lei, Zhaozhao Jiang, and Katherine A. Fitzgerald

PNAS June 29, 2021 118 (26) e2100383118; https://doi.org/10.1073/pnas.2100383118
You have access
The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism
Alexander C. Y. Foo, Peter M. Thompson, Shih-Heng Chen, Ramesh Jadi, Brianna Lupo, Eugene F. DeRose, Simrat Arora, Victoria C. Placentra, Lakshmanane Premkumar, Lalith Perera, Lars C. Pedersen, Negin Martin, and Geoffrey A. Mueller

PNAS March 16, 2021 118 (11) e2019251118; https://doi.org/10.1073/pnas.2019251118
Open Access
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Yu-Pu Juang, Hsiu-Hua Ma, Ying-Ta Wu, Wen-Bin Yang, Cheng-Wei Cheng, Xiaorui Chen, Ting-Hung Chou, Jiun-Jie Shie, Wei-Chieh Cheng, Rong-Jie Chein, Shi-Shan Mao, Pi-Hui Liang, Che Ma, Shang-Cheng Hung, and Chi-Huey Wong

PNAS February 2, 2021 118 (5) e2021579118; https://doi.org/10.1073/pnas.2021579118
Open Access
Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections
Katherine M. Almasy, Jonathan P. Davies, Samantha M. Lisy, Reyhaneh Tirgar, Sirena C. Tran, and Lars Plate

PNAS January 19, 2021 118 (3) e2012209118; https://doi.org/10.1073/pnas.2012209118
Open Access
Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
Łukasz F. Sobala, Pearl Z. Fernandes, Zalihe Hakki, Andrew J. Thompson, Jonathon D. Howe, Michelle Hill, Nicole Zitzmann, Scott Davies, Zania Stamataki, Terry D. Butters, Dominic S. Alonzi, Spencer J. Williams, and Gideon J. Davies

PNAS November 24, 2020 117 (47) 29595-29601; first published November 5, 2020. https://doi.org/10.1073/pnas.2013620117
Open Access
Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
Emmie de Wit, Friederike Feldmann, Jacqueline Cronin, Robert Jordan, Atsushi Okumura, Tina Thomas, Dana Scott, Tomas Cihlar, and Heinz Feldmann

PNAS March 24, 2020 117 (12) 6771-6776; first published February 13, 2020. https://doi.org/10.1073/pnas.1922083117
Open Access
Circadian control of interferon-sensitive gene expression in murine skin
Elyse Noelani Greenberg, Michaela Ellen Marshall, Suoqin Jin, Sanan Venkatesh, Morgan Dragan, Lam C. Tsoi, Johann E. Gudjonsson, Qing Nie, Joseph S. Takahashi, and Bogi Andersen

PNAS March 17, 2020 117 (11) 5761-5771; first published March 4, 2020. https://doi.org/10.1073/pnas.1915773117

Main menu

User menu

Search

New Research In

antiviral

Pages

Articles

PNAS Portals

Information

Main menu

User menu

Search

New Research In

Physical Sciences

Featured Portals

Articles by Topic

Social Sciences

Featured Portals

Articles by Topic

Biological Sciences

Featured Portals

Articles by Topic

antiviral

Pages

Articles

PNAS Portals

Information