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cancer

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Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia
Osvaldo D. Rivera, Michael J. Mallory, Mathieu Quesnel-Vallières, Rakesh Chatrikhi, David C. Schultz, Martin Carroll, Yoseph Barash, Sara Cherry, and Kristen W. Lynch

PNAS April 13, 2021 118 (15) e2014967118; https://doi.org/10.1073/pnas.2014967118
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Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage
Alexandra M. Amen, Christof Fellmann, Katarzyna M. Soczek, Shawn M. Ren, Rachel J. Lew, Gavin J. Knott, Jesslyn E. Park, Andrew M. McKinney, Andrew Mancini, Jennifer A. Doudna, and Joseph F. Costello

PNAS March 30, 2021 118 (13) e2008772118; https://doi.org/10.1073/pnas.2008772118
Open Access
Paradoxical androgen receptor regulation by small molecule enantiomers
Katherin Patsch, Chao Liu, Grzegorz Zapotoczny, Yuanye Sun, Harish Sura, Nolan Ung, Ren X. Sun, Bethany Haliday, Chen Yu, Mayada Aljehani, Jerry S. H. Lee, Boris A. Kashemirov, David B. Agus, Charles E. McKenna, and Daniel Ruderman

PNAS March 23, 2021 118 (12) e2100918118; https://doi.org/10.1073/pnas.2100918118
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A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses
Di Chen, Arghyashree Roychowdhury-Sinha, Pragya Prakash, Xiao Lan, Wenmin Fan, Akira Goto, and Jules A. Hoffmann

PNAS March 23, 2021 118 (12) e2100825118; https://doi.org/10.1073/pnas.2100825118
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Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants
Zahra Moghadamchargari, Mehdi Shirzadeh, Chang Liu, Samantha Schrecke, Charles Packianathan, David H. Russell, Minglei Zhao, and Arthur Laganowsky

PNAS March 23, 2021 118 (12) e2022403118; https://doi.org/10.1073/pnas.2022403118
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Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis
Karim Mrouj, Nuria Andrés-Sánchez, Geronimo Dubra, Priyanka Singh, Michal Sobecki, Dhanvantri Chahar, Emile Al Ghoul, Ana Bella Aznar, Susana Prieto, Nelly Pirot, Florence Bernex, Benoit Bordignon, Cedric Hassen-Khodja, Martin Villalba, Liliana Krasinska, and Daniel Fisher

PNAS March 9, 2021 118 (10) e2026507118; https://doi.org/10.1073/pnas.2026507118
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Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation
Kartik N. Rajagopalan, Xiao Chen, Daniel N. Weinberg, Haifen Chen, Jacek Majewski, C. David Allis, and Chao Lu

PNAS March 2, 2021 118 (9) e2021795118; https://doi.org/10.1073/pnas.2021795118
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ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor–activated cancer
Bo Tang, Rui Sun, Dejie Wang, Haoyue Sheng, Ting Wei, Liguo Wang, Jun Zhang, Thai H. Ho, Lu Yang, Qiang Wei, and Haojie Huang

PNAS February 23, 2021 118 (8) e2019052118; https://doi.org/10.1073/pnas.2019052118
Open Access
Evolutionary dynamics at the tumor edge reveal metabolic imaging biomarkers
Juan Jiménez-Sánchez, Jesús J. Bosque, Germán A. Jiménez Londoño, David Molina-García, Álvaro Martínez, Julián Pérez-Beteta, Carmen Ortega-Sabater, Antonio F. Honguero Martínez, Ana M. García Vicente, Gabriel F. Calvo, and Víctor M. Pérez-García

PNAS February 9, 2021 118 (6) e2018110118; https://doi.org/10.1073/pnas.2018110118
Open Access
A general fragment-based approach to identify and optimize bioactive ligands targeting RNA
Blessy M. Suresh, Weichao Li, Peiyuan Zhang, Kye Won Wang, Ilyas Yildirim, Christopher G. Parker, and Matthew D. Disney

PNAS December 29, 2020 117 (52) 33197-33203; first published December 14, 2020. https://doi.org/10.1073/pnas.2012217117

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