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cancer

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Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics
Colin G. Buss and Sangeeta N. Bhatia

PNAS first published June 3, 2020. https://doi.org/10.1073/pnas.2001569117
Open Access
Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy
Aadra P. Bhatt, Samuel J. Pellock, Kristen A. Biernat, William G. Walton, Bret D. Wallace, Benjamin C. Creekmore, Marine M. Letertre, Jonathan R. Swann, Ian D. Wilson, Jose R. Roques, David B. Darr, Sean T. Bailey, Stephanie A. Montgomery, Jeffrey M. Roach, M. Andrea Azcarate-Peril, R. Balfour Sartor, Raad Z. Gharaibeh, Scott J. Bultman, and Matthew R. Redinbo

PNAS March 31, 2020 117 (13) 7374-7381; first published March 13, 2020. https://doi.org/10.1073/pnas.1918095117
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Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents
Grégory Thiabaud, Guangan He, Sajal Sen, Kathryn A. Shelton, Wallace B. Baze, Luke Segura, Julie Alaniz, Ruben Munoz Macias, Greg Lyness, Alan B. Watts, Hyun Min Kim, Hyunseung Lee, Mi Young Cho, Kwan Soo Hong, Rick Finch, Zahid H. Siddik, Jonathan F. Arambula, and Jonathan L. Sessler

PNAS March 31, 2020 117 (13) 7021-7029; first published March 16, 2020. https://doi.org/10.1073/pnas.1914911117
Open Access
Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology
Catherine Fan, Paul A. Davison, Robert Habgood, Hong Zeng, Christoph M. Decker, Manuela Gesell Salazar, Khemmathin Lueangwattanapong, Helen E. Townley, Aidong Yang, Ian P. Thompson, Hua Ye, Zhanfeng Cui, Frank Schmidt, C. Neil Hunter, and Wei E. Huang

PNAS March 24, 2020 117 (12) 6752-6761; first published March 6, 2020. https://doi.org/10.1073/pnas.1918859117
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Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine
Xui-Fen Liu, Junxia Wei, Qi Zhou, Bruce A. Molitoris, Ruben Sandoval, Hisataka Kobayashi, Ryuhei Okada, Tadanobu Nagaya, Baktiar Karim, Donna Butcher, and Ira Pastan

PNAS March 17, 2020 117 (11) 6086-6091; first published March 2, 2020. https://doi.org/10.1073/pnas.1919038117
Open Access
The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells
David A. Anderson III, Theresa L. Murphy, Robert N. Eisenman, and Kenneth M. Murphy

PNAS March 3, 2020 117 (9) 4885-4893; first published February 18, 2020. https://doi.org/10.1073/pnas.1915060117
Open Access
In situ genetic engineering of tumors for long-lasting and systemic immunotherapy
Stephany Y. Tzeng, Kisha K. Patel, David R. Wilson, Randall A. Meyer, Kelly R. Rhodes, and Jordan J. Green

PNAS February 25, 2020 117 (8) 4043-4052; first published February 7, 2020. https://doi.org/10.1073/pnas.1916039117
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Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects
Zhihua Jiao, Huaqing Cai, Yu Long, Orit Katarina Sirka, Veena Padmanaban, Andrew J. Ewald, and Peter N. Devreotes

PNAS February 25, 2020 117 (8) 4158-4168; first published February 12, 2020. https://doi.org/10.1073/pnas.1917938117
Open Access
Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy
Andreane Cartier, Tani Leigh, Catherine H. Liu, and Timothy Hla

PNAS February 11, 2020 117 (6) 3157-3166; first published January 27, 2020. https://doi.org/10.1073/pnas.1906246117
Open Access
Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer
Matthew G. Costales, Haruo Aikawa, Yue Li, Jessica L. Childs-Disney, Daniel Abegg, Dominic G. Hoch, Sai Pradeep Velagapudi, Yoshio Nakai, Tanya Khan, Kye Won Wang, Ilyas Yildirim, Alexander Adibekian, Eric T. Wang, and Matthew D. Disney

PNAS February 4, 2020 117 (5) 2406-2411; first published January 21, 2020. https://doi.org/10.1073/pnas.1914286117

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