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cancer therapy

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The SHREAD gene therapy platform for paracrine delivery improves tumor localization and intratumoral effects of a clinical antibody
Sheena N. Smith, Rajib Schubert, Branko Simic, Dominik Brücher, Markus Schmid, Niels Kirk, Patrick C. Freitag, Viviana Gradinaru, and Andreas Plückthun

PNAS May 25, 2021 118 (21) e2017925118; https://doi.org/10.1073/pnas.2017925118
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Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo
Xingkang He, Xin Yin, Jing Wu, Stina L. Wickström, Yanhong Duo, Qiqiao Du, Shuhang Qin, Shuzhong Yao, Xu Jing, Kayoko Hosaka, Jieyu Wu, Lasse D. Jensen, Andreas Lundqvist, Alexander I. Salter, Lars Bräutigam, Wei Tao, Yuguo Chen, Rolf Kiessling, and Yihai Cao

PNAS September 15, 2020 117 (37) 22910-22919; first published August 28, 2020. https://doi.org/10.1073/pnas.2009092117
Open Access
FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination
Elaine Guo, Yuki Ishii, James Mueller, Anjana Srivatsan, Timothy Gahman, Christopher D. Putnam, Jean Y. J. Wang, and Richard D. Kolodner

PNAS August 11, 2020 117 (32) 19415-19424; first published July 27, 2020. https://doi.org/10.1073/pnas.2009237117
See companion article:
Draining the FEN1s for cancer therapy
- Aug 18, 2020
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High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D
Malcolm J. W. Sim, Jinghua Lu, Matthew Spencer, Francis Hopkins, Eric Tran, Steven A. Rosenberg, Eric O. Long, and Peter D. Sun

PNAS June 9, 2020 117 (23) 12826-12835; first published May 27, 2020. https://doi.org/10.1073/pnas.1921964117
Open Access
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance
Lance R. Thomas, Clare M. Adams, Jing Wang, April M. Weissmiller, Joy Creighton, Shelly L. Lorey, Qi Liu, Stephen W. Fesik, Christine M. Eischen, and William P. Tansey

PNAS December 10, 2019 116 (50) 25260-25268; first published November 25, 2019. https://doi.org/10.1073/pnas.1910391116
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Rapid screening of engineered microbial therapies in a 3D multicellular model
Tetsuhiro Harimoto, Zakary S. Singer, Oscar S. Velazquez, Joanna Zhang, Samuel Castro, Taylor E. Hinchliffe, William Mather, and Tal Danino

PNAS April 30, 2019 116 (18) 9002-9007; first published April 17, 2019. https://doi.org/10.1073/pnas.1820824116
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Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression
Hongbo Zhang, Wenguo Cui, Xiangmeng Qu, Huayin Wu, Liangliang Qu, Xu Zhang, Ermei Mäkilä, Jarno Salonen, Yueqi Zhu, Zhou Yang, Dong Chen, Hélder A. Santos, Mingtan Hai, and David A. Weitz

PNAS April 16, 2019 116 (16) 7744-7749; first published March 29, 2019. https://doi.org/10.1073/pnas.1817251116
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Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity
Masanori Onda, Kazuto Kobayashi, and Ira Pastan

PNAS March 5, 2019 116 (10) 4575-4582; first published February 13, 2019. https://doi.org/10.1073/pnas.1820388116
Open Access
Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus
Nadishka Jayawardena, Laura N. Burga, Richard A. Easingwood, Yoshimasa Takizawa, Matthias Wolf, and Mihnea Bostina

PNAS November 13, 2018 115 (46) E10934-E10940; first published October 31, 2018. https://doi.org/10.1073/pnas.1810664115
See companion article:
Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1
- Dec 04, 2018
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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy
Meng Qiu, Dou Wang, Weiyuan Liang, Liping Liu, Yin Zhang, Xing Chen, David Kipkemoi Sang, Chenyang Xing, Zhongjun Li, Biqin Dong, Feng Xing, Dianyuan Fan, Shiyun Bao, Han Zhang, and Yihai Cao

PNAS January 16, 2018 115 (3) 501-506; first published January 2, 2018. https://doi.org/10.1073/pnas.1714421115

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