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cancer therapy

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High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D
Malcolm J. W. Sim, Jinghua Lu, Matthew Spencer, Francis Hopkins, Eric Tran, Steven A. Rosenberg, Eric O. Long, and Peter D. Sun

PNAS June 9, 2020 117 (23) 12826-12835; first published May 27, 2020. https://doi.org/10.1073/pnas.1921964117
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Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance
Lance R. Thomas, Clare M. Adams, Jing Wang, April M. Weissmiller, Joy Creighton, Shelly L. Lorey, Qi Liu, Stephen W. Fesik, Christine M. Eischen, and William P. Tansey

PNAS December 10, 2019 116 (50) 25260-25268; first published November 25, 2019. https://doi.org/10.1073/pnas.1910391116
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Rapid screening of engineered microbial therapies in a 3D multicellular model
Tetsuhiro Harimoto, Zakary S. Singer, Oscar S. Velazquez, Joanna Zhang, Samuel Castro, Taylor E. Hinchliffe, William Mather, and Tal Danino

PNAS April 30, 2019 116 (18) 9002-9007; first published April 17, 2019. https://doi.org/10.1073/pnas.1820824116
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Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression
Hongbo Zhang, Wenguo Cui, Xiangmeng Qu, Huayin Wu, Liangliang Qu, Xu Zhang, Ermei Mäkilä, Jarno Salonen, Yueqi Zhu, Zhou Yang, Dong Chen, Hélder A. Santos, Mingtan Hai, and David A. Weitz

PNAS April 16, 2019 116 (16) 7744-7749; first published March 29, 2019. https://doi.org/10.1073/pnas.1817251116
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Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity
Masanori Onda, Kazuto Kobayashi, and Ira Pastan

PNAS March 5, 2019 116 (10) 4575-4582; first published February 13, 2019. https://doi.org/10.1073/pnas.1820388116
Open Access
Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus
Nadishka Jayawardena, Laura N. Burga, Richard A. Easingwood, Yoshimasa Takizawa, Matthias Wolf, and Mihnea Bostina

PNAS November 13, 2018 115 (46) E10934-E10940; first published October 31, 2018. https://doi.org/10.1073/pnas.1810664115
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Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1
- Dec 04, 2018
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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy
Meng Qiu, Dou Wang, Weiyuan Liang, Liping Liu, Yin Zhang, Xing Chen, David Kipkemoi Sang, Chenyang Xing, Zhongjun Li, Biqin Dong, Feng Xing, Dianyuan Fan, Shiyun Bao, Han Zhang, and Yihai Cao

PNAS January 16, 2018 115 (3) 501-506; first published January 2, 2018. https://doi.org/10.1073/pnas.1714421115
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Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy
Yin Zhang, Meili Sun, Guichun Huang, Linlin Yin, Qinghua Lai, Yunlong Yang, Xiaoming Xing, Guohua Yu, Yuping Sun, Xinsheng Wang, Guohui Nie, Yizhi Liu, and Yihai Cao

PNAS June 27, 2017 114 (26) E5226-E5235; first published June 12, 2017. https://doi.org/10.1073/pnas.1705066114
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Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis
Xiu Fen Liu, Laiman Xiang, Qi Zhou, Jean-Philippe Carralot, Marco Prunotto, Gerhard Niederfellner, and Ira Pastan

PNAS September 20, 2016 113 (38) 10666-10671; first published September 6, 2016. https://doi.org/10.1073/pnas.1611481113
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Bioengineered yeast-derived vacuoles with enhanced tissue-penetrating ability for targeted cancer therapy
Vipul Gujrati, Miriam Lee, Young-Joon Ko, Sangeun Lee, Daejin Kim, Hyungjun Kim, Sukmo Kang, Soyoung Lee, Jinjoo Kim, Hyungsu Jeon, Sun Chang Kim, Youngsoo Jun, and Sangyong Jon

PNAS January 19, 2016 113 (3) 710-715; first published December 29, 2015. https://doi.org/10.1073/pnas.1509371113

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